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Two Clinical Trials Approved: First Milestone Achieved!

MBI has reached its first milestone: two clinical trials were approved this year!

The MATCHPOINT study, approved in February 2024, will test a treatment combining patient-derived T-cell immunotherapy with a drug aimed at overcoming tumor resistance. Meanwhile, the RNA vaccine study, approved in April 2024, will explore the person's ability to develop immunity to disease recurrence through an mRNA vaccine.

Two Clinical Trials Approved: First Milestone Achieved!

MBI has reached its first milestone: two clinical trials were approved this year!

The MATCHPOINT study, approved in February 2024, will test a treatment combining patient-derived T-cell immunotherapy with a drug aimed at overcoming tumor resistance. Meanwhile, the RNA vaccine study, approved in April 2024, will explore the person's ability to develop immunity to disease recurrence through an mRNA vaccine.

FDA approves the first clinical trials for the cure of medulloblastoma

New September Report highlights MBI’s latest achievements

In an inspiring move, kids come together to raise funds for MBI!

The
Medulloblastoma
Initiative

The Medulloblastoma Initiative (MBI) was established in 2021 to materialize the vision shared by Brazilian entrepreneur Fernando Goldsztein and Dr. Roger J. Packer, based at the Children's National Hospital in Washington DC.. The MBI raises private resources that are channeled to the research on Group 4 medulloblastoma developed by the Cure Group 4 Consortium — which includes 13 laboratories installed in the US, Canada, and Germany. Medulloblastoma is the most common pediatric brain cancer. Nevertheless, the treatment protocol used today has not changed since the 1980s.

In addition to not curing a large proportion of the children affected by medulloblastoma, current treatments impose severe, life-lasting side effects to the children who survive. And this is why the MBI works to connect private donors to  great scientists.

Join us — "whoever saves one life saves the world entire".

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MATCHPOINT:

Has medulloblastoma met its match?

Duane Mitchell, MD, PhD, co-director of the University of Florida’s Preston A. Wells Jr. Center for Brain Tumor Therapy, leads the MATCHPOINT trial. The therapy harnesses adoptive cell therapy (ACT), which programs a patient’s T cells (white blood cells critical to the body) to seek and destroy cancer cells. In a previous study (ReMATCH), Dr. Mitchell’s lab demonstrated ACT’s significant promise as a safe and effective treatment for relapsed medulloblastoma. One patient saw a nearly total elimination of widespread metastatic disease.

"The ultimate goal is we want to cure kids"

SCIENTIFIC INSTITUTIONS
INTEGRATING THE CONSORTIUM

IN THE MEDIA

Every year, about 25,000 children worldwide are diagnosed with medulloblastoma, the most common type of childhood brain cancer. It primarily affects children aged 4 to 9...

After receiving the news that his son had cancer, Brazilian businessman Fernando Goldsztein created an innovative research model and, in record time, secured approval...

In June 2024, VEJA magazine published the statement given by Fernando Goldsztein, Founder of The Medulloblastoma Initiative, to journalist Simone Blanes.

Journalist Kelly Matos, from Zero Hora—one of Brazil's leading newspapers—wrote a heartfelt column about cancer cures and the work of MBI

"I intend to work for the rest of my life for pediatric cancer. I am sure that this group of scientists will find the cure for medulloblastoma...

Jennifer Griffin (Fox News) reports on Fernando Goldsztein and the Medulloblastoma Initiative's efforts to fight the most common form of pediatric brain cancer

Created by a businessman from Rio Grande do Sul, MBI searches for funds to finance the research to combat medulloblasma. The global initiative raised USD 10 million in two years. In six months, the consortium of laboratories financed by the project has already made significant discoveries.

What is medulloblastoma? What are the late effects of treatment? Ana Lourenço addresses these topics and tells how MBI came about and its mission to find a cure for medulloblastoma. “We have to persevere and keep going. We can’t give up.” says Fernando Goldsztein, founder of the project.

Fernando Goldsztein, MBI founder, tells the reasons for creating the project and how it has grown exponentially since its foundation. “A parent’s heartfelt thought: children should be immune to cancer!”, he declares.

The columnist Daniel Scola talks about his experience at the 1st International Symposium on Pediatric Neuro-Oncology, reporting his experience as a survivor and commenting on the importance that initiatives such as MBI have in the development of new treatments.

On Father's Day, journalist Cláudia Colucci and Folha de S.Paulo tell the story of MBI, which supports a consortium of laboratories seeking a cure for medulloblastoma — an initiative born from the experience of a father and a child facing this cancer.

Fernando Goldsztein's report on the MBI was published in the MIT Sloan School of Management newsletter.. Not by chance, MBI's story made it onto the list of the top 10 alumni stories in 2022.

The research supported the MBI to find a cure of medulloblastoma, the most common brain cancer in children, will soon begin clinical trials. For this new stage, in the coming months, MBI will seek $7 million in private donations.

"My son's illness changed my life,” says Fernando Goldsztein, MBI founder. He left an executive position at a large real estate company to support research aimed at finding a cure for medulloblastoma.

How did MBI start, and what difference can philanthropic donations make in advancing scientific research? "I never imagined the impact could be so significant," the founder of MBI told Brazil Journal.

In 2021, Brazilian journalist Daniel Scola was diagnosed with medulloblastoma. "I was among those saved thanks to science,,” he wrote when reporting about the MBI, "an innovative project that will greatly contribute to health globally".

A (lemonade) toast to Ava and friends
Supported by her family and hard-working friends, Ava Strong, a kid with brain cancer, sold enough lemonade to raise U$ 225 for medulloblastoma research — and spread their message of hope on social media.

The funds were channeled through MBI to the Research Consortium led by Dr. Roger J. Packer, from Children's National Hospital in Washington DC.

Thank you Ava for helping the MBI fulfill its mission — to support the best worldwide research that will find a cure for medulloblastoma.
A voice supporting our cause

It was through the words of journalist Daniel Scola that many people first heard about MBI. As a journalist and a medulloblastoma survivor, Scola understands the power of sharing his story and has published the book Apprentice of the Storm. We highly recommend giving it a read!
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GOING ON AT MBI

Weathering the storm together

It was a night to celebrate: MBI founder Fernando Goldsztein had the honor of stepping on stage together with MBI partner and medulloblastoma survivor Daniel Scola.

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